Thesis

52 Chapter 2 Table e-5. Relationship between ATN categories and cognition in control group without SCD (continued) Baseline Longitudinal Non-AD pathologic change Alzheimer’s continuum Non-AD pathologic change Alzheimer’s continuum Animal fluency -2.48 (1.27) 0.88 (1.70) 0.14 (0.73) -0.96 (1.00) TMT-A -0.03 (0.06) 0.02 (0.08) -0.01 (0.03) -0.08 (0.04) TMT-B -0.01 (0.07) -0.03 (0.09) -0.07 (0.03) -0.05 (0.04) Values given are Beta (SE), corrected for age, sex, education, as estimated by Linear Mixed Models (reference category: normal AD biomarkers). Beta baseline = association between ATN category and baseline test result. Beta longitudinal = association with annual decline. Note that TMT-A and TMT-B are log transformed and inversed. * p-value remaining significant after FDR correction with q set at 0.05 VAT=Visual Association Test; RAVLT=Rey Auditory Verbal Learning Test; TMT=Trail Making Test

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