51 ATN classification in subjective cognitive decline Table e-4. Relationship between ATN categories and baseline and longitudinal cognition in three ATN categories in SCD (continued) Baseline Longitudinal Non-AD pathologic change Alzheimer’s continuum Non-AD pathologic change Non-AD pathologic change TMT-A -0.01 (0.03) -0.04 (0.04) -0.04 (0.04) -0.04 (0.02)* TMT-B -0.04 (0.03) -0.06 (0.04) -0.06 (0.04) -0.07 (0.02)* Stroop I -0.00 (0.02) -0.00 (0.02) -0.00 (0.02) -0.02 (0.01)* Stroop II -0.01 (0.02) -0.04 (0.02) -0.04 (0.02) -0.03 (0.01)* Stroop III -0.01 (0.02) -0.04 (0.03) -0.04 (0.03) -0.04 (0.01)* Values given are Beta (SE), corrected for age, sex, education, as estimated by Linear Mixed Models (reference category: normal AD biomarkers). Beta baseline = association between ATN category and baseline test result. Beta longitudinal = association with annual decline. Note that TMT-A, TMT-B, Stroop I, Stroop II, Stroop III are log transformed and inversed. * p-value remaining significant after FDR correction with q set at 0.05 VAT=Visual Association Test; RAVLT=Rey Auditory Verbal Learning Test; TMT=Trail Making Test Table e-5. Relationship between ATN categories and cognition in control group without SCD Baseline Longitudinal Non-AD pathologic change Alzheimer’s continuum Non-AD pathologic change Alzheimer’s continuum VAT-A 0.05 (0.17) -0.55 (0.23) 0.02 (0.11) 0.01 (0.15) RAVLT immediate recall 0.31 (1.57) -2.44 (2.12) -1.24 (0.79) -1.78 (1.10) RAVLT delayed recall -0.18 (0.51) -0.66 (0.70) -0.19 (0.27) -0.57 (0.38) Digit span forward -0.31 (0.38) -0.09 (0.51) 0.08 (0.19) -0.06 (0.26) Digit span backward -0.33 (0.34) -0.05 (0.45) -0.29 (0.18) -0.33 (0.25) 2
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