The studies described in this thesis were carried out at the Alzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam Amsterdam UMC. Research of the Alzheimer Center is part of the Neurodegeneration program of Amsterdam Neuroscience. The Alzheimer Center is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The SCIENCe project is funded by GieskesStrijbis fonds. Printing of this thesis was supported by stichting Alzheimer Nederland, stichting Alzheimer & Neuropsychiatry Foundation and Vrije Universiteit Amsterdam. ISBN: 978-94-6421-816-9 Layout and design: Wiebke Keck, persoonlijkproefschrift.nl Printed by: Ipskamp Printing © Jarith Laurien Ebenau, Amsterdam, The Netherlands, 2022. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without prior permission of the copyright holder, or, when applicable, with permission of the publishers of the scientific journals.