33 ATN classification in subjective cognitive decline Subsequently, we ran an additional analysis to assess the putative combined effect of memory impairment and amyloid status. We found that the effects of memory and amyloid positivity seem additive, as – compared to individuals with a high RAVLT delayed recall score and no evidence of amyloid – those with both a low RAVLT delayed recall score and positive amyloid were at the highest risk of dementia (HR 18.9 (5.5-64.6); Table 3). Participants with only a low baseline memory were not at increased risk of dementia (HR 1.2 (0.1-11.0)), but participants with only a positive A biomarker alone were (HR 8.8 (2.3-34.2)). Table 3. Association between baseline Rey Auditory Verbal Learning Test (RAVLT) delayed recall score and clinical progression Cox proportional hazard models N Total progression, n (%) Progression to dementiaa Progression to MCI or dementiaa A- High RAVLT 206 7 (3%) 1 (reference) 1 (reference) A- Low RAVLT 49 6 (12%) 1.2 (0.1-11.0) 5.0 (1.6-15.7) A+ High RAVLT 49 15 (31%) 8.8 (2.3-34.2) 9.6 (3.7-25.0) A+ Low RAVLT 23 14 (61%) 18.9 (5.5-64.6) 37.3 (14.2-97.9) Abbreviation: MCI= mild cognitive impairment a: Cox proportional hazard models, adjusted for age, sex and education. Data is presented as Hazard Ratio (HR) (95% CI). 2