30 Chapter 2 Table 1. Baseline demographics, PET, CSF, and MRI values in eight-profile ATN classification (continued) A-T-NN=385 (55.6%) A-T-N+ N=39 (5.6%) A-T+NN=137 (19.8%) A-T+N+ N=10 (1.4%) A+T-NN=43 (6.2%) A+T-N+ N=14 (2.0%) A+T+NN=54 (7.8%) A+T+N+ N=11 (1.6%) P-value MRI MTA, mean (SD)b 0.2 (0.3) 1.2 (0.3) 0.2 (0.3) 1.3 (0.4) 0.3 (0.4) 1.4 (0.4) 0.3 (0.4) 1.5 (0.5) 0.00a GCA, mean (SD) 0.2 (0.4) 0.7 (0.6) 0.4 (0.6) 0.5 (0.9) 0.3 (0.5) 0.6 (0.6) 0.4 (0.5) 0.6 (0.8) 0.00a PA, mean (SD) b 0.4 (0.6) 0.7 (0.8) 0.6 (0.7) 0.6 (0.8) 0.5 (0.5) 0.6 (0.5) 0.7 (0.6) 1.1 (0.8) 0.00a Fazekas, mean (SD) 0.5 (0.6) 0.7 (0.8) 0.6 (0.6) 0.8 (0.8) 0.8 (0.7) 1.1 (0.9) 0.9 (0.7) 0.9 (0.8) 0.00a Lacunes, n (%)c 12 (3.1%) 2 (5.1%) 8 (5.8%) 1 (10.0%) 0 (0.0%) 1 (8.3%) 4 (7.4%) 1 (9.1%) 0.13 Microbleeds, n (%)c 3 9 (10.3%) 8 (21.1%) 16 (11.9%) 0 (0.0%) 8 (18.6%) 3 (23.1%) 13 (24.1%) 5 (45.5%) 0.00a Abbreviations: Aβ = β-amyloid; GCA=global cortical atrophy; GDS=geriatric depression scale; MMSE=mini-mental state examination; MTA=medial temporal atrophy; p-tau = phosphorylated threonine 181; PA=parietal atrophy. Analyses were performed using analysis of variance and Fisher’s exact test. Education is rated using the Dutch Verhage system (43). a: p-value <0.05. b: average between left and right side. c: values are dichotomized into 0 counts and ≥1 counts. N shown is number of participants with ≥1 counts.
RkJQdWJsaXNoZXIy MjY0ODMw