Thesis

29 ATN classification in subjective cognitive decline Table 1. Baseline demographics, PET, CSF, and MRI values in eight-profile ATN classification A-T-NN=385 (55.6%) A-T-N+ N=39 (5.6%) A-T+NN=137 (19.8%) A-T+N+ N=10 (1.4%) A+T-NN=43 (6.2%) A+T-N+ N=14 (2.0%) A+T+NN=54 (7.8%) A+T+N+ N=11 (1.6%) P-value Demographics Age, mean (SD) 57.2 (8.3) 59.0 (9.0) 61.1 (8.7) 60.0 (7.5) 62.8 (7.1) 65.8 (9.3) 66.7 (6.6) 68.8 (9.9) 0.00a Sex, n female (%) 155 (40.3%) 11 (28.2%) 55 (40.1%) 4 (40.0%) 20 (46.5%) 5 (35.7%) 29 (53.7%) 4 (36.4%) 0.41 Education, mean (SD) 5.4 (1.3) 5.5 (1.1) 5.5 (1.3) 4.7 (1.3) 5.3 (1.4) 5.8 (1.4) 5.5 (1.2) 5.3 (0.9) 0.41 MMSE, mean (SD) 28 (2) 28 (2) 28 (2) 27 (2) 28 (1) 28 (2) 28 (1) 28 (2) 0.46 APOE ε4 carriers, n (%) 103 (27.2%) 13 (35.1%) 51 (38.6%) 3 (30.0%) 25 (59.5%) 8 (57.1%) 35 (68.6%) 7 (63.6%) 0.00a Depressive symptoms GDS score, mean (SD) 3.1 (2.5) 3.1 (3.3) 3.2 (3.0) 4.2 (2.0) 2.5 (2.5) 3.2 (4.5) 2.6 (3.2) 2.0 (1.8) 0.63 Amyloid PET Amyloid PET, n positive/ total (N=105) 0/54 0/8 0/17 0/2 8/8 1/1 14/14 1/1 0.00a CSF Aβ, mean (SD) (N=588) 1125.2 (154.9) 1116.4 (203.9) 1213.2 (204.3) 1149.1 (244.7) 698.9 (100.5) 690.4 (122.0) 654.3 (105.6) 620.0 (103.0) 0.00a P-tau, mean (SD) 38.1 (8.6) 36.8 (11.0) 66.0 (12.1) 76.8 (40.9) 41.3 (9.7) 32.1 (9.1) 87.3 (31.9) 95.5 (55.4) 0.00a Total Tau, mean (SD) 215.8 (74.0) 210.1 (67.5) 400.2 (130.9) 532.4 (375.1) 251.3 (80.8) 182.2 (70.0) 629.9 (329.9) 622.4 (337.9) 0.00a 2

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