189 Summary and general discussion REFERENCES 1. Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chetelat G, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2014;10(6):844-52. 2. Slot RER, Verfaillie SCJ, Overbeek JM, Timmers T, Wesselman LMP, Teunissen CE, et al. Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results. Alzheimers Res Ther. 2018;10(1):76. 3. Rabin LA, Smart CM, Amariglio RE. Subjective Cognitive Decline in Preclinical Alzheimer’s Disease. Annu Rev Clin Psychol. 2017;13:369-96. 4. Rodríguez-Gómez O, Abdelnour C, Jessen F, Valero S, Boada M. Influence of Sampling and Recruitment Methods in Studies of Subjective Cognitive Decline. Journal of Alzheimer’s disease : JAD. 2015;48 Suppl 1:S99-s107. 5. Janssen O, Jansen WJ, Vos SJB, Boada M, Parnetti L, Gabryelewicz T, et al. Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2021. 6. van der Flier WM, Scheltens P. Amsterdam Dementia Cohort: Performing Research to Optimize Care. Journal of Alzheimer’s disease : JAD. 2018;62(3):1091-111. 7. Rodriguez-Gomez O, Sanabria A, Perez-Cordon A, Sanchez-Ruiz D, Abdelnour C, Valero S, et al. FACEHBI: A Prospective Study of Risk Factors, Biomarkers and Cognition in a Cohort of Individuals with Subjective Cognitive Decline. Study Rationale and Research Protocols. The journal of prevention of Alzheimer’s disease. 2017;4(2):100-8. 8. Jessen F, Spottke A, Boecker H, Brosseron F, Buerger K, Catak C, et al. Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE). Alzheimer’s research & therapy. 2018;10(1):15-. 9. Jack CR, Jr., Wiste HJ, Weigand SD, Therneau TM, Knopman DS, Lowe V, et al. Age-specific and sex-specific prevalence of cerebral beta-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional study. The Lancet Neurology. 2017;16(6):435-44. 10. Soldan A, Pettigrew C, Fagan AM, Schindler SE, Moghekar A, Fowler C, et al. ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes. Neurology. 2019;92(14):e1567-e79. 11. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Jr., Kawas CH, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2011;7(3):263-9. 12. Floud S, Balkwill A, Sweetland S, Brown A, Reus EM, Hofman A, et al. Cognitive and social activities and long-term dementia risk: the prospective UK Million Women Study. Lancet Public Health. 2021;6(2):e116-e23. 8