Thesis

169 Longitudinal change in biomarkers Associations between changes in amyloid status and cognitive test performance Finally, we investigated whether change in amyloid burden was associated with cognitive test performance over time, using our four-level variable (negative-negative (reference), positive-negative, negative-positive, positive-positive) as determinant. We did not find associations between change in amyloid status and baseline cognitive test performance (Table 4). By contrast, we found several associations with cognitive slope, as individuals in the negative-positive group had a steeper slope than negative-negative individuals on Stroop I and III. Positive-positive individuals showed a steeper decline on RAVLT immediate and delayed recall, TMT-B and Stroop III. Positive-negative individuals did not differ from negative-negative individuals with regards to their cognitive test performance. Table 4. Associations between change in amyloid burden and cognitive test performance Baseline Longitudinal Positivenegative Negativepositive Positivepositive Positivenegative Negativepositive Positivepositive VAT-A 0.20 (0.30) 0.16 (0.21) 0.05 (0.16) 0.01 (0.11) 0.03 (0.05) 0.01 (0.04) RAVLT immediate 3.24 (3.36) 0.65 (2.40) -2.28 (1.88) -0.11 (0.88) 0.04 (0.36) -1.40 (0.32)* RAVLT delayed 0.88 (1.18) 0.55 (0.85) -0.96 (0.66) -0.03 (0.30) 0.05 (0.12) -0.51 (0.10)* Animal fluency 3.48 (2.13) 1.42 (1.51) 0.79 (1.18) 0.71 (0.57) -0.05 (0.23) -0.23 (0.21) TMT-A 0.01 (0.11) 0.13 (0.08) 0.05 (0.06) 0.03 (0.04) -0.04 (0.02) -0.01 (0.02) TMT-B 0.04 (0.13) 0.10 (0.10) -0.07 (0.08) 0.01 (0.03) -0.02 (0.01) -0.02 (0.01)* Stroop I 0.05 (0.07) 0.06 (0.05) 0.01 (0.04) 0.01 (0.02) -0.03 (0.01)* -0.01 (0.01) Stroop II 0.06 (0.07) 0.00 (0.05) 0.04 (0.04) 0.00 (0.02) -0.02 (0.01) -0.02 (0.01) 7

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