166 Chapter 7 Figure 3. Changes in amyloid status Scatterplot showing baseline and follow-up BPND values. Different colors represent individuals with a negative amyloid PET scan at baseline and follow-up (negativenegative), a positive scan at baseline and a negative scan at follow-up (positive-negative), a negative scan at baseline and a positive scan at follow-up (negative-positive), and a positive scan at baseline and follow-up (positive-positive), respectively. The dashed lines represent a division in low, grey zone and high amyloid burden and is based on a previous study by our group(6), with thresholds of 0.19 and 0.29 BPND. BPND = binding potential. Subsequently, we investigated which factors predicted a change in amyloid status from negative to positive. Logistic regression analysis showed that APOE ε4 carriers had higher odds of transitioning to a positive amyloid status (OR 5.22 (95% CI 1.2322.75), Table 2). Baseline age, sex, education and baseline MMSE score were not associated with a higher odds of changing to amyloid positivity. When we analyzed amyloid accumulation rate as continuous outcome using linear mixed models (BPND; Table 3, Figure 4), we confirmed that APOE ε4 carriers had both higher baseline BPND values and a higher accumulation rate.
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