145 Cerebral blood flow, amyloid burden and cognition Table 4. Associations with cross-sectional and longitudinal BPND Region Concurrent Longitudinal Model 1 Frontal 0.09 (0.07) -0.08 (0.02)* Temporal -0.06 (0.07) -0.03 (0.01) Parietal -0.01 (0.07) -0.02 (0.01) Occipital 0.14 (0.07) 0.00 (0.02) Composite -0.06 (0.07) -0.04 (0.01)* Model 2 Frontal 0.09 (0.08) -0.08 (0.02)* Temporal 0.04 (0.08) -0.03 (0.01) Parietal 0.05 (0.08) -0.02 (0.01) Occipital 0.18 (0.08) 0.00 (0.02) Composite 0.02 (0.08) -0.04 (0.01)* Notes: Results shown are beta (SE) as estimated by linear mixed models, outcome is BPND. In model 1, the predictors are R1, time between PET scans in years and the interaction R1*time. Model 2 is additionally corrected for age, sex and PET and MRI scanner type. Values given represent beta associated with R1 (concurrent) and R1*time (longitudinal). Models included a random intercept. R1 and BPND are z-transformed. Bold P value < 0.05. * FDR corrected P value < 0.05. 6
RkJQdWJsaXNoZXIy MjY0ODMw