142 Chapter 6 Table 2. Relationship between R1, BPND and cognition in composite region of interest (continued) Concurrent Longitudinal Model 1 Model 2 Model 3 Model 1 Model 2 Model 3 R1 BPND R1 BPND R1*time BPND*time R1*time BPND*time Stroop II 0.00 (0.01) -0.01 (0.01) 0.00 (0.01) -0.01 (0.01) 0.00 (0.00) -0.01 (0.00)* 0.00 (0.00) -0.01 (0.00)* Stroop III 0.00 (0.01) 0.00 (0.02) -0.01 (0.01) 0.00 (0.02) 0.00 (0.00) -0.01 (0.00)* 0.00 (0.00) -0.01 (0.00)* MMSE -0.08 (0.07) -0.21 (0.07) -0.08 (0.07) -0.21 (0.07) 0.04 (0.02) -0.05 (0.02) 0.04 (0.02) -0.05 (0.02) Notes: Values given are beta (SE) obtained via linear mixed models. Outcome: cognitive test performance. Predictors: Model 1: R1, time, R1*time; Model 2: BPND, time, BPND*time; Model 3: R1, BPND, time, R1*time, BPND*time. For all neuropsychological tests as outcome, we tested whether the interaction term R1*BPND*time was significant. When this was the case, we show the betas of R1*time and BPND*time of the model that included this three-way interaction term. All models were corrected for age, sex, education and PET and MRI scanner type. Betas reflect the association with annual decline (interaction between predictor and time). Models included a random intercept, and a random slope was added for RAVLT immediate, RAVLT delayed, Stroop II, Stroop III and MMSE. TMT and Stroop were log transformed and inverted. R1 and BPND are z-transformed. Abbreviations: SE = standard error, VAT = visual association test, RAVLT = rey auditory verbal learning task, TMT = trail making test, MMSE = mini-mental state examination. Bold P value < 0.05. * FDR corrected P value < 0.05. † interaction term R1*BPND*time P value < 0.05.
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