139 Cerebral blood flow, amyloid burden and cognition Relationship between BPND, R1 and cognition We first analyzed how both baseline PET markers were associated with cognitive performance (Table 2, Figure 1). We did not find any cross-sectional associations between R1 and any of the cognitive tests (model 1). By contrast, we found effects of R1 on slope of several tests (p for interaction with time <0.05). A lower baseline R1 was associated with a worse trajectory for tests for memory (RAVLT immediate and delayed), attention (TMT-A) and global cognition (MMSE), but not for tests in other cognitive domains. Next, we used baseline BPND as predictor in our models (model 2). We only found a cross-sectional association between a higher baseline BPND and a lower MMSE score. By contrast, we found effects of BPND on slope for a large number of tests. When we simultaneously entered BPND and R1 in model 3, results remained essentially unchanged. Testing for interactions between the two measures of Alzheimer pathology, we found an interaction between R1 and BPND for slope of RAVLT immediate (betaR1*BP*time -0.23 (SE 0.09)), such that the effect of R1 on RAVLT immediate slopes was mainly present in individuals with low BPND. There was no interaction for any of the other neuropsychological tests, implying independent effects on cognitive decline of BPND and R1. 6
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