138 Chapter 6 Table 1. Baseline demographics (continued) Total N=187 BPND Occipital 0.20 (0.009) 0.00 (0.002) BPND Composite 0.17 (0.010) 0.01 (0.002)* Relative cerebral R1 Frontal 0.93 (0.004) 0.01 (0.002)* blood flow R1 Temporal 0.89 (0.004) 0.00 (0.001)* R1 Parietal 0.95 (0.004) -0.00 (0.002)* R1 Occipital 0.98 (0.004) -0.00 (0.002) R1 Composite 0.92 (0.004) 0.00 (0.010) Neuropsychological VAT-A 11.53 (0.053) -0.04 (0.013)* tests RAVLT immediate 44.77 (0.594) 0.62 (0.150)* RAVLT delayed 8.99 (0.196) 0.11 (0.048)* Animal fluency 23.56 (0.364) 0.02 (0.061) TMT-A§ -3.47 (0.020) -0.00 (0.003) TMT-B§ -4.32 (0.024) -0.00 (0.003) Stroop I§ -3.75 (0.011) 0.00 (0.002) Stroop II§ -4.05 (0.012) 0.01 (0.002)* Stroop III§ -4.52 (0.016) 0.02 (0.003)* MMSE 28.76 (0.071) 0.05 (0.024) Notes: Baseline demographics in the total sample. Data is presented as mean (SE) unless otherwise specified. Values for BPND, R1 and cognitive test results do not represent the observed data but are obtained using linear mixed models with time as only predictor (intercept as concurrent value at time of baseline PET scan; beta associated with time as value for annual change). Annual change for BPND and R1 is based on the subset with an available follow-up PET (n=83). Abbreviations: BPND = binding potential, VAT = visual association test, RAVLT = rey auditory verbal learning task, TMT = trail making test, MMSE = Mini Mental State Examination. * P value <0.05. † Amyloid positivity as determined by visual assessment of baseline [18F]florbetapir PET ‡ Values are dichotomized into 0 counts and ≥ 1 counts, n shown is number of participants with ≥ 1 count. § Values are log transformed and inverted such that a lower score implies a worse test result, complicating interpretation of values.
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