116 Chapter 5 Figure 3. Combined effect of APOE ε4 and PRS on risk of clinical progression to AD dementia Kaplan Meier curve showing the combined effects of APOE ε4 and the PRS on risk of progression to AD dementia, comparing (1) APOE ε4 non-carrier and low PRS, (2) APOE ε4 non-carrier and high PRS, (3) APOE ε4 carrier and low PRS, and (4) APOE ε4 carrier and high PRS. APOE ε4 status is determined by having one or two ε4 alleles, PRS status is based on median risk. PRS = polygenic risk score, AD = Alzheimer’s disease.
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