112 Chapter 5 We corrected all logistic regression analyses for age, sex and population substructure (principal components 1-10). The Cox proportional hazards models were additionally adjusted for baseline score on the mini-mental state examination (MMSE). All analyses were done using R version 3.6.0. We used the survival package version 2.44.1-1 for Cox proportional hazards analyses. RESULTS Demographics At baseline, individuals were on average 60±9 years old, 339 (41%) were female and MMSE was 28±2 (Table 1). The largest subgroup was that with normal AD biomarkers (57%), followed by non-AD pathologic change (26%) and the Alzheimer’s continuum (17%). Among the 491 individuals with available follow-up, 41 (8%) received a diagnosis of dementia (AD dementia n=25, other types of dementia n=16). Table 1. Demographics Total N=829 Demographics Age, mean (SD) 59.6 (8.8) Sex, n (% female) 339 (40.9) Education, median (IQR) 6 (5-6) MMSE, mean (SD) 28.3 (1.6) Follow-up Follow-up time in years, mean (SD) 3.6 (2.8) Progression to dementia All-type dementia, n (%) 41 (8.4) AD dementia, n (%) 25 (5.1) Other dementia, n (%) 16 (3.3) Follow-up information available n=491 Biomarkers Amyloid status, n positive / n total (%) 106/655 (16.2) Tau status, n positive / n total (%) 193/644 (30.0) Neurodegeneration status, n positive / n total (%) 77/703 (11.0) Baseline characteristics of the total sample. MMSE = mini-mental state examination, AD = Alzheimer’s disease.