109 Risk of dementia related to APOE ε4 and a polygenic risk score the eight biomarker profiles into three categories. The ‘normal AD biomarker’ category consisted of the biomarker profile with all normal biomarkers (A-T-N-). ‘NonAD pathologic change’ consisted of the remaining A- profiles (A-T-N+, A-T+N- and A-T+N+). The ‘Alzheimer’s continuum’ consisted of all A+ profiles (A+T-N-, A+T-N+, A+T+N-, A+T+N+) (1). Figure 1. Flowchart of participant selection SCD = subjective cognitive decline; ADC Amsterdam dementia cohort SCIENCe = subjective cognitive impairment cohort FU = follow-up 5