103 Markers of neurodegeneration in subjective cognitive decline Data shown are hazard ratio (95% confidence interval) as estimated by Cox proportional hazards analyses (outcome: clinical progression to mild cognitive impairment or dementia). Predictors included differed per model (model 1: neurodegeneration biomarker; model 2: neurodegeneration biomarker, age and sex; model 3: Aβ, neurodegeneration biomarker, age and sex; model 4: Aβ, p-tau, neurodegeneration biomarker, age and sex). In models with MTA and HV, scanner type was additionally added as covariate. P-tau, t-tau, NfL and GFAP were log transformed, Aβ and hippocampal volume were inverted, all biomarkers were z-transformed. MTA = medial temporal atrophy, HV = hippocampal volume, NfL = neurofilament light, GFAP = glial fibrillary acidic protein. a p-value < 0.05. T-tau was not entered in model 4 due to collinearity between t-tau and p-tau. b FDR corrected p-value < 0.05. eTable 2. Risk of cognitive decline for continuous N biomarkers for complete cases Biomarker Model 1 Model 2 Model 3 Model 4 T-tau -0.22 (0.04)a,b -0.22 (0.05)a,b -0.20 (0.05)a,b MTA -0.07 (0.06) -0.06 (0.06) -0.04 (0.06) -0.03 (0.06) HV -0.15 (0.05)a,b -0.18 (0.05)a,b -0.17 (0.05)a,b -0.17 (0.05)a,b NfL -0.09 (0.05) -0.07 (0.06) -0.04 (0.07) -0.03 (0.06) GFAP -0.18 (0.05)a,b -0.17 (0.06)a,b -0.13 (0.06)a -0.11 (0.06) Results shown are β (SE) as estimated by linear mixed models. Outcome is MMSE score. Predictors: model 1: neurodegeneration, time, neurodegeneration*time; model 2: variables included in model 1, age, sex, age*time and sex*time; model 3: variables included in model 2, CSF Aβ and Aβ *time; model 4: variables included in model 3, CSF p-tau and p-tau*time). In models with MTA and HV, scanner type was additionally added as covariate. Βs represent the interaction between neurodegeneration biomarker and time, which corresponds to the cognitive slope. P-tau, t-tau, NfL and GFAP were log transformed, Aβ and hippocampal volume ere inverted, all biomarkers were z-transformed. MTA = medial temporal atrophy, HV = hippocampal volume, NfL = neurofilament light, GFAP = glial fibrillary acidic protein. T-tau was not entered in model 4 due to collinearity between t-tau and p-tau. a p-value < 0.05. b FDR corrected p-value < 0.05. 4
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