Thesis

102 Chapter 4 SUPPLEMENTARY MATERIAL eText 1 The following acquisition parameters were used to acquire structure MRI 3D T1weighted images: 1.5T Siemens Avanto (n=5): Magnetization prepared rapid acquisition gradient echo (MPRAGE), coronal plane, repetition time (TR) 2700 ms, echo time (TE) 5.2 ms, inversion time (TI) 950 ms, flip angle (FA) 8°, voxel size 1×1×1.5 mm3; 3T GE Discovery MR750 (n=9): FSPGR, sagittal plane, TR 7.8 ms, TE 3ms, FA 12°, voxel size 1 mm3; 1T Siemens Magnetom Impact (n=106): MPRAGE, coronal plane, TR 15 ms, TE 7 ms, TI 300 ms, FA 15°, voxel size 1×1×1.5 mm3; 3T Philips Ingenuity PET/MR system (n=47): sagittal turbo field echo (TFE), sagittal plane, TR 7 ms, TE 3 ms, FA 12°, voxel size 1×1×1 mm3; 1.5T GE SignaHDxt (n=8): sagittal fast spoiled gradient echo (FSPGR), sagittal plane, TR 12.4 ms, TE 5.17 ms, TI 450 ms, FA 12°, voxel size 0.98×0.98×1.5 mm3; 3T GE SignaHDxt (n=119): FSPGR, sagittal plane, TR 708 ms, TE 7 ms, FA 12°, voxel size 0.98×0.98×1 mm3; 1.5T Siemens Sonata (n=18): MPRAGE, coronal plane, TR 2700 ms, TE 3.97 ms, TI 950 ms, FA 8°, voxel size 1×1×1.5 mm3; Toshiba Titan 3T (n=53): sagittal fast field echo (FFE) sequence (TR = 9, TE = 3, TI = 800, FA = 7°, 1.00 x 1.00 x 1.00 mm voxels); 1.5T Siemens Vision (n=1): MPRAGE, coronal plane, TR 15 ms, TE 7 ms, FA 8°, voxel size 0.98×0.98×1.5 mm3. eTable 1. Risk of MCI or dementia for continuous N biomarkers for complete cases Model 1 Model 2 Model 3 Model 4 Biomarker n HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI) T-tau 256 2.26 (1.74 - 2.94)a,b 1.98 (1.47 - 2.67)a,b 1.57 (1.16 - 2.11)a,b MTA 256 1.53 (1.16 - 2.02)a,b 1.18 (0.86 - 1.62) 1.00 (0.72 - 1.39) 1.01 (0.72 - 1.40) HV 256 1.65 (1.18 - 2.30)a,b 1.52 (1.06 - 2.18)a,b 1.47 (1.04 - 2.07)a,b 1.52 (1.06 - 2.16)a,b NfL 256 1.83 (1.40 - 2.39)a,b 1.49 (1.04 - 2.13)a,b 1.30 (0.86 - 1.94) 1.31 (0.87 - 1.98) GFAP 256 2.47 (1.80 - 3.38)a,b 2.08 (1.45 - 2.99)a,b 1.49 (1.00 - 2.22)a 1.43 (0.96 - 2.12)

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