Thesis

GENERAL INTRODUCTION 23 1 stage two of the PRPP-Assessment, a cognitive task analysis incorporates the scoring of the conceptual stages of information processing influencing task performance. This task analysis includes 35 items divided into four quadrants: perceive, recall, plan and perform. Each quadrant is divided into three sub-quadrants, which includes the underlying items called descriptors (see Figure 4). The assessment can be administered based on life observations or videomaterial.73-75 The PRPP-Assessments can be applied to the whole target group of children with mitochondrial disorder, because it fits with the necessary requirements based on the PEO-model; the activity can be chosen by the child, they can perform the activity in their usual way in the actual context, and the assessment can be used with all different age groups and levels of functioning. In addition, most children with mitochondrial disorder experience information-processing difficulties and this is even more hindered when they are fatigued. The clinical utility of the PRPP-­ Assessment is good78-80 and psychometric properties have been studied in several target groups, for example adults and children with and without disabilities81, children with learning difficulties82, children with autism and intellectual disabilities83, school-aged children84, 85, adults with disabilities86, traumatic brain injury87-89, Parkinson’s’ disease90, 91, schizophrenia92, 93, dementia94, 95, and stroke96 or cancer97 survivors, and is also used as an outcome measure in research82-84, 88, 89, 98-102. Based on these studies, the reliability, validity and responsiveness can be concluded as being sufficient to good. Also clinical utility was positively evaluated in three Figure 3 Revised version (2011) of the Occupational Performance Model (Australia)76, 77

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