44 PART ONE | CISPLATIN-INDUCED ACUTE KIDNEY INJURY Conclusions AKI is a frequent complication of high-dose cisplatin-based CRT for patients with LA-SCCHN, despite adherence to guideline-consistent prevention therapy. CINV and hypertension are potentially modifiable, and highly significant risk factors contributing to AKI. Studies investigating strategies to minimize AKI after highdose cisplatin-based CRT for patients with LA-SCCHN are warranted.
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