38 PART ONE | CISPLATIN-INDUCED ACUTE KIDNEY INJURY Predictors for cisplatin-induced AKI Hypertension, ≥2 nephrotoxic co-medications, excessive alcohol consumption, and CINV were variables in the univariate analysis with an association p< 0.20 with cisplatin-induced AKI (Table 2). Table 2. Univariate and multivariate logistic regression for AKI (KDIGO). Variables OR (95% CI) Univariate p-value OR (95% CI) Multivariate p-value Age, ≥60 years 1.1 (0.5-2.3) 0.85 Male gender 0.9 (0.4-2.2) 0.81 ECOG performance status, ≥2 0.4 (0.1-2.3) 0.34 Hypertension, yes 2.1 (0.7-6.1) 0.17 2.7 (1.1-6.6) 0.03 Diabetes, yes 1.7 (0.3-8.4) 0.54 Cognitive impairment, yes 0.4 (0.1-1.8) 0.25 CCI, ≥ 2 1.5 (0.5-4.1) 0.45 Number of nephrotoxic co-medications, ≥ 2 2.1 (0.8-5.4) 0.12 1.9 (0.7-5.2) 0.20 Smoking, ≥10 pack-years 1.4 (0.6-3.4) 0.39 Alcohol, ≥14 U/week 1.8 (0.8-4.0) 0.17 2.3 (0.7-7.0) 0.15 Primary tumor site, not oropharynx 0.6 (0.3-1.5) 0.32 CINV, yes 3.0 (1.2-7.3) 0.02 4.3 (1.6-11.3) 0.003 Abbreviations: CCI, Age-adjusted Charlson Comorbidity Index; CI, Confidence Interval; CINV, chemotherapy-induced nausea and vomiting; ECOG, Eastern Cooperative Oncology Group Performance Status Score; KDIGO, Kidney Disease Improving Global Outcomes definition and staging system; OR, Odds Ratio Bold values in the univariate logistic regression model indicate p-values <0.20 as criterion for selection and entry into the multivariate analysis. Significant p-values in the multivariate analysis model (<0.05) are also denoted in bold. The multivariate logistic regression model shows that hypertension (Odds Ratio (OR) 2.7, 95% Confidence Interval (CI) 1.1-6.6; p= 0.03), and CINV (OR 4.3, 95% CI 1.6-11.3; p= 0.003) were significantly associated with cisplatin-induced AKI.
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