Thesis

36 PART ONE | CISPLATIN-INDUCED ACUTE KIDNEY INJURY Table 1. Baseline patient and tumor characteristics. Data given as No. (%), unless otherwise noted. Characteristic Total (N= 124) AKI (n= 85) Non-AKI (n= 39) Median age, (range), years 60 (30-74) 60 (30-71) 59 (41-74) Male 97 (78) 67 (79) 30 (77) ECOG performance status 0 41 (33) 26 (31) 15 (38) 1 2 Not specified 76 (61) 6 (5) 1 (1) 55 (65) 3 (4) 1 (1) 21 (54) 3 (8) Hypertension 25 (20) 20 (24) 5 (13) Diabetes mellitus 9 (7) 7 (8) 2 (5) Cognitive impairment 8 (6) 4 (5) 4 (10) CCI 0-1 2-3 92 (74) 32 (26) 61 (72) 24 (28) 31 (79) 8 (21) Smoking ≥10 pack-years 92 (74) 65 (76) 27 (69) Alcohol ≥14 Units/week 46 (37) 35 (41) 11 (28) Number of nephrotoxic comedications, median (range) 2 (0-3) 2 (0-3) 2 (1-3) Mean sCr (SD), µmol/l 66 (12) 66 (12) 65 (12) Primary site Oral cavity / oropharynx 88 (71) 58 (68) 30 (77) Hypopharynx Larynx Other 15 (12) 17 (14) 4 (3) 12 (14) 12 (14) 3 (4) 3 (8) 5 (13) 1 (3) Tumor stage T1-2 46 (37) 29 (34) 17 (44) T3-4 69 (56) 51 (60) 18 (46) Unknown 6 (5) 5 (6) 1 (3) Nodal stage N0 N+ Unknown 15 (12) 106 (85) 3 (2) 12 (14) 71 (84) 2 (2) 3 (8) 35 (90) 1 (3) Abbreviations: CCI, Age-adjusted Charlson Comorbidity Index; ECOG, Eastern Cooperative Oncology Group Performance Status Score (WHO); sCr, serum Creatinine (μmol/L); SD, Standard Deviation

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