35 2 CISPLATIN-INDUCED ACUTE KIDNEY INJURY | PART ONE Statistics Descriptive analyses were used to describe patient and treatment characteristics and the incidence of AKI. To indicate predictors for cisplatin-induced AKI, univariate analysis was used to analyze the association between AKI and age (<60 years vs, ≥60 years), sex, ECOG performance status score before start of treatment (<2 vs. ≥2), presence of hypertension (defined as systolic pressure >140 millimeters of mercury (mmHg) or diastolic pressure >90 mmHg) before start of treatment (yes vs. no), presence of diabetes mellitus (yes vs. no), presence of cognitive impairment (yes vs. no), number of nephrotoxic co-medications taken in the week before start of CRT (<2 vs. ≥2), number of pack-years (<10 years or ≥10 years), excessive alcohol consumption (<14 units per week or ≥14 units per week), primary LA-SCCHN tumor site (oropharyngeal vs. non-oropharyngeal), and occurrence of clinically relevant CINV (defined as administration of rescue antiemetics and/or hospital admission to provide targeted care for CINV) during treatment. Variables in the univariate logistic regression analysis with an association p< 0.20 were included as independent variables into the multivariate logistic regression model. In the multivariate analysis model, p values <0.05 were considered statistically significant. The paired samples t test was used to compare mean sCr values at baseline, and at three and twelve months post-treatment, in both patients with AKI during treatment, and those without (non-AKI patients). The independent samples t test was used to compare the means of sCr values between AKI and non-AKI patients at baseline, and at three and twelve months post-treatment. Kaplan-Meier and log-rank methods were used to compare the curves of DFS and DSM between AKI and non-AKI patients. Analyses were performed with IBM SPSS statistics version 22 (Chicago, IL, United States). Results A total of 124 patients were included in this study. The median age was 60 years (range, 30 to 74 years), 78% of patients were male, and 94% had ECOG performance status 0 to 1 (Table 1). Twenty percent of patients had hypertension, age-adjusted CCI score was 0 to 1 in 74% of patients. Most patients (74%) had a smoking history of ≥10 pack-years, and 20% indicated excessive use of alcohol. Median number of potentially nephrotoxic comedications was 2 (range, 0 to 3).
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