Thesis

140 PART THREE | DELIRIUM Supplementary materials Table S2. Dose adjustment algorithm for olanzapine On day 1, olanzapine was increased with repeating dosing of 5.0 mg every 2 hours until delirium resolved. Maximum dose allowed was 20 mg (both orally and intramuscularly) per 24 hours. Maintenance dose was one half of the total dose of olanzapine administered during the first 24 hours, which was divided in 1 or 2 doses. The loading, titration, maintenance, and maximum dose of olanzapine was halved for patients ≥75 years of age. Maintenance dose on day 2 was one half of the total dose of olanzapine administered during the first 24 hours, which was divided in 1 or 2 doses. Olanzapine Day 2: maintenance dose Total dose (mg) day 1* Evening dose (mg) Morning dose (mg) Rescue dose (mg; maximum once daily) Total dose (mg) day 2** 2.5 2.5 0 2.5 5 5 2.5 0 2.5 5 7.5 2.5 2.5 2.5 7.5 10 2.5 2.5 2.5 7.5 15 5 2.5 2.5 10 20 5 5 5 15 *Total dose ended .5 are rounded up **With maximum use of rescue dose On day 2, delirium assessment with DRS-R-98 is repeated. Resolution of delirium was defined as a DRS-R-98 total severity score of <15.25 points with a ≥4.5 points reduction in the severity items scores. If on day 3 the severity score of DRS-R-98 is ≥15.25 points, maintenance dose of haloperidol is increased according to the following guideline. Olanzapine Day 3: maintenance dose Total dose (mg) day 2* Evening dose (mg) Morning dose (mg) Rescue dose (mg; maximum once daily) Total dose (mg) day 3** 5 5 2.5 2.5 10 7.5 5 5 2.5 12.5 10 7.5 5 5 12.5 15 10 7.5 2.5 20 *Total dose ended .5 are rounded up ** With maximum use of rescue dose

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