54 CHAPTER 2 DS & DF BoNT-A did not lead to a significant reduction in DS after 8 or 32 weeks. 2-DL did lead to a significant decrease in DS after 8-weeks (table 2), but this did not persist after 32 weeks. There was a significant reduction in DF both 8 and 32 weeks after BoNT-A. This reduction was greater after 2-DL. Procedural time Per-protocol analysis showed that, on average, BoNT-A was a significantly shorter procedure than 2-duct ligation (6:13 minutes vs. 21:23 minutes). Adverse events There were more adverse events after 2-DL than after BoNT-A (40.7% vs 19.2%, difference = 21.5%, CI -11.2-54.2%) (Table 3). There were three cases of serious adverse events which included three admissions: one patient due to nausea postoperatively which was related to the intervention, one patient due to nausea unrelated to the intervention and one patient for dehydration due to gastroenteritis which was unrelated to the intervention. All other complications were related to the intervention except for one patient with pharyngitis. There was no long-lasting disability as all adverse events had resolved within 6 weeks and there were no cases of wound infection, postoperative bleeding or ranula formation warranting surgical re-intervention. Complaints Thirty-nine out of 53 patients completed the postoperative complaints diary (Table 3). The total number of days of complaints was significantly lower (difference 6.5 days, 95% CI 4.0-8.9) after BoNT-A (mean 3.1 ± 3.6 days) than after 2-DL (mean 9.6 ± 3.9 days).
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