28 CHAPTER 1 Figure 1: Mean drooling quotient and visual analogue scale (VAS) over time. Linear graph showing the trend in time of the mean drooling quotient and VAS at baseline and 8-week assessment per injection. Error bars show standard error. Our analysis showed that the number of injection (injection 1, 2, or 3) was associated with a lower value indicating improvement on the drooling quotient (p=0.016) and VAS (p=0.002) after 8 weeks. This indicates that the subjective (VAS) and objective (drooling quotient) reduction is lower after the second injection than after the first injection (slope [b]=–5.20; 95% confidence interval [CI]=–8.72 to –1.68 and b=–12.74; 95% CI=–19.78 to –5.70 for drooling quotient and VAS respectively). The reduction (∆) in VAS was lower after the third injection compared to the first injection (b=–10.35; 95% CI=–20.62 to –0.87) (Fig. 2). The analysis was corrected for age: 8 years 2 months for (∆) drooling quotient and 8 years for (∆) VAS. The reduction in drooling quotient did not differ significantly between the third and first injection.
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