211 months; therefore a patient has enough time to think about participation after receiving the patients information. Informed consent will be obtained by the researcher after the patient has had minimally 24 hours to consider. Informed consent will be signed by the researcher and the patient (if mentally competent) or the legal representative who often are the parents or caregivers. When patients are mentally competent and aged ≥ 12 years, both the patient and the legal representative(s) will sign the informed consent form. In case there are two legal representatives, both will sign the informed consent form. Almost all patients with chronic drooling complaints have a (severe) developmental delay and are incapacitated for normal functioning. All parents/caregivers give their full consent to participate, and the only way to conduct the study is with this group of patients. It would not be possible to execute this study only on adult and legally competent patients. Benefits and risks assessment, group relatedness Benefits of this study relay to improved treatment of drooling in children and adolescents with neurodevelopmental disabilities. Treatment should be carefully considered in this vulnerable patient population. The results of this study will potentially result in a less invasive treatment modality. These results will probably lead to future research evaluating E-2DL compared to submandibular gland extirpation or submandibular duct relocation, which are both more invasive treatment modalities. The results of this pilot study will possibly affect future therapy. In this study, two additional questionnaires will be obtained. Radiation due to radiographs made to visualize the submandibular duct while infusing ethanol will presumably be neglectable. Previous literature revealed that one would only need an effective radiation dose of 130 μSv to visualize the submandibular gland (which includes one panoramic, one standard mandibular occlusal and four lateral skull radiographs). In contrast, the worldwide annual average background radiation dose is approximately 2.6mSv.95
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