206 FUTURE RESEARCH Inclusion criteria 1. Moderate to severe drooling indicated by Drooling Frequency Score ≥ 3 or Drooling Severity Score ≥ 2. 2. Aged 10 years and older. 3. Cerebral palsy or any other non-progressive neurodevelopmental disability. 4. Contra-indications for SMDR, or rejection towards SMDR by patient or caregivers* 5. Ability and willingness to follow the study protocol and attend the 8 and 32-weeks visits. 6. Written and informed consent from caregivers, and when appropriate, oral consent from the child. * contra-indication for SMDR: - posterior drooling - pharyngeal dysphagia as judged by the speech and language therapist. - progressive neurodisability as judged by the child neurologist. Exclusion criteria 1. Medical history of salivary gland abnormalities like ductal stenosis, strictures 2. Previous submandibular salivary gland surgery or other contraindications for surgery or general anaesthesia. 3. Recent (<6 months) glandular Botulinum Neurotoxin A (BoNT-A) injection 4. Simultaneous alternative treatment for drooling. Primary outcome 1. Feasibility of the procedure by adverse events, complaints, and surgical time. 1. Adverse events. 2. Post-operative complaints All parameters will be compared to the previous results of 2-DL without the infusion of ethanol in this institution.
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