140 CHAPTER 6 Figure 1 presents an overview of the average direct (related to and not related to the procedure) and indirect costs and distribution over the three intervals. The costs made over the three intervals in the BoNT-A and the two-duct ligation groups were both significantly atypical. The estimating equations in the generalized linear model showed that the cost ratio of BoNT-A compared with two-duct ligation was 61.1% wherein the average cost per BoNT-A treatment cycle was €1929 (standard error 62) and that for the two-duct ligation group was €3155 (standard error 99). €84 €85 €142 €593 €43 €40 €456 €512 €272 €348 €245 €231 €686 €1.345 €1.227 €1.942 €414 €941 €288 €271 0 200 400 600 800 1000 1200 1400 1600 1800 2000 BoNT-A 2-DL BoNT-A 2-DL BoNT-A 2-DL T1 T2 T3 Costs per interval Indirect costs Direct costs * Direct costs related to the procedure ^ Figure 1. Costs per interval. The ICER was calculated as the incremental costs divided by the incremental effectiveness. The incremental costs were calculated as the difference between the total costs for two-duct ligation and the total costs for BoNT-A. The incremental effectiveness was the difference between the treatment success proportion for two-duct ligation and that for BoNT-A (0.63−0.27=0.36). The ICER was €34.06 per 1% gain of success when using two-duct ligation instead of BoNT-A, which was calculated by dividing the mean total cost difference of €1226 (€3155−€1929) by the difference in treatment success (36%).
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