118 CHAPTER 5 the caregivers reported damage. Caregivers of children treated with 2-DL noticed a significant reduction of damage to electronic devices from 30% (8 of 27) at baseline to 11% (3 of 27) 8 weeks after surgery, which remained 11% 32 weeks after treatment. The difference in damage reduction compared to BoNT-A was statistically significant after 32 weeks (p = 0·032, B = 1·77, 95% CI 1·2 to 29·7). Drooling causing damage to floors and/or furniture was reported by 27% (7 of 26) of the caregivers before BoNT-A treatment, which diminished to 19% (5 of 26) and 12% (3 of 26) after 8 and 32 weeks respectively. Damage to floors and/or furniture due to drooling in children assigned to 2-DL was reported by 15% (4 of 27) of the caregivers at baseline. Eight weeks after surgery none of the caregivers reported any damage to floors and/or furniture, while after 32 weeks this rate had risen to 11% (3 of 27). A significant difference between the effect of BoNT-A and 2-DL on damage to floors and/or furniture was not found. Social interaction Drooling appeared to have a negative impact on social interactions as illustrated by table 2. Both treatments had a positive, yet non-significant influence on the social interaction at 8 and 32 weeks after treatment. The impression of caregivers on the child’s satisfaction on his/her social contact with other children and physical appearance during the past 4 weeks did improve but showed no significant difference. The child's satisfaction on their relations within the family as perceived by their caretakers improved 17·6 points (mean difference 17·6, p = <0·001, 95% CI 9·0 to 26·2) 8 weeks after 2-DL and 10·5 points 32 weeks after 2-DL (mean difference 10·5, p = 0·015, 95% CI -1·9 to -0·2). Likewise, the child's satisfaction on life in general improved after 2-DL with respectively a 17·6 (mean difference 17·6, p = <0·001, 95% CI 9·7 to 25·6) and a 12·5 (p = 0·003, 95% CI 4·2 to 20·7) point improvement on the 0-100 VAS after 8 and 32 weeks. Following BoNT-A, there was no significant improvement at either 8 or 32 weeks. A significant difference between 2-DL and BoNT-A was not found.
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