116 CHAPTER 5 Daily care Baseline values for BoNT-A and 2-DL were equal (p = >0·05) in all three conditions. Both BoNT-A and 2-DL decreased the amount of hourly wiping after 8 and 32 weeks, but 2-DL had a larger effect than BoNT-A during follow-up (mean difference 4·1, F[1,51]= 8·660, p = 0·002; 95% CI 1·5 to 6·7) (figure 2). Caregivers of children treated with BoNT-A encouraged their children to swallow a mean of 2·3 times per hour at baseline. Hourly encouragement to swallow nonsignificantly decreased to 1·8 times per hour after 8 weeks (p = 0·44, 95% CI -0·8 to 1·8) and showed no further change from 8 to 32 weeks (p = 0·96, 95% CI -1·1 to 1·0). After 2-DL the hourly encouragement to swallow decreased from 3·6 to 1·6 (p = 0·009, 95% CI 0·5 to 3·6) at 8 weeks, and to 1·7/hour (p = 0·027, 95% CI 0·2 to 3·6) after 32 weeks, which was not significantly different from BoNT-A (mean difference 0·17, F[1,51]=0·267 p = 0·655; 95% CI -0·6 to 0·9) (figure 2). 2-DL reduced the mean number of bib or shawl changes for the collection of saliva from 6 to 4·2 times a day after 8 weeks (p = 0·05, 95% CI 0·0 to 3·5) and to 3 times a day 32 weeks after treatment (p = 0·039, 95% CI 0·2 to 5·7). BoNT-A did not significantly change the mean number of bib or shawl changes after 8 and 32 weeks. The difference in reduction induced by 2-DL in comparison to BoNT-A turned out to be non-significant (mean difference 0·63, F[1,51]= 0·411, p = 0·516; 95% CI -1·3 to 2·5).
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