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184 Chapter 8 31 Yamagata K, Sugimura M, Yoshida M et al. Estrogens Exacerbate Nociceptive Pain via Up-Regulation of TRPV1 and ANO1 in Trigeminal Primary Neurons of Female Rats. Endocrinology 2016; 157 (11): 4309-4317. 32 Goadsby PJ. Pathophysiology of migraine. Ann Indian Acad Neurol 2012; 15 (Suppl 1): S15-S22. 33 Valdemarsson S, Edvinsson L, Hedner P et al. Hormonal influence on calcitonin gene-related peptide in man: effects of sex difference and contraceptive pills. Scand J Clin Lab Invest 1990; 50 (4): 385-388. 34 Godley F, 3rd, Meitzen J, Nahman-Averbuch H et al. How Sex Hormones Affect Migraine: An Interdisciplinary Preclinical Research Panel Review. J Pers Med 2024; 14 (2). 35 Gupta S, Mehrotra S, Villalón CM et al. Potential role of female sex hormones in the pathophysiology of migraine. Pharmacol Ther 2007; 113 (2): 321-340. 36 Puri V, Cui L, Liverman CS et al. Ovarian steroids regulate neuropeptides in the trigeminal ganglion. Neuropeptides 2005; 39 (4): 409-417. 37 Chen Q, Zhang W, Sadana N et al. Estrogen receptors in pain modulation: cellular signaling. Biol Sex Differ 2021; 12 (1): 22. 38 Amandusson Å, Blomqvist A. Estrogenic influences in pain processing. Frontiers in Neuroendocrinology 2013; 34 (4): 329-349. 39 Eikermann-Haerter K, Dileköz E, Kudo C et al. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest 2009; 119 (1): 99-109. 40 Warfvinge K, Krause DN, Maddahi A et al. Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects. J Headache Pain 2020; 21 (1): 131. 41 Martin VT, Behbehani M. Ovarian hormones and migraine headache: understanding mechanisms and pathogenesis--part I. Headache 2006; 46 (1): 3-23. 42 Martin VT, Behbehani M. Ovarian hormones and migraine headache: understanding mechanisms and pathogenesis--part 2. Headache 2006; 46 (3): 365-386. 43 Mittelman-Smith MA, Williams H, Krajewski-Hall SJ et al. Arcuate kisspeptin/ neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology 2012; 153 (6): 2800-2812. 44 Uenoyama Y, Inoue N, Nakamura S et al. Kisspeptin Neurons and EstrogenEstrogen Receptor α Signaling: Unraveling the Mystery of Steroid Feedback System Regulating Mammalian Reproduction. Int J Mol Sci 2021; 22 (17). 45 Neill JD, Johansson ED, Datta JK et al. Relationship between the plasma levels of luteinizing hormone and progesterone during the normal menstrual cycle. J Clin Endocrinol Metab 1967; 27 (8): 1167-1173.

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