173 Estradiol and other sex-hormone dynamics in menstrual migraine 8 Figure 2. Estradiol (pmol/L) with 95% CI on each day after the LH surge for patients with menstrual migraine (red) versus healthy controls (blue). Data is back-transformed after log2 transformation to make the y-axis interpretable. Asterisks present significant change compared with baseline: *p < 0.05. Delta (Δ) represents the decline in estradiol from day 8 to day 14 after the LH surge. Primary outcome Peak plasma estradiol levels during the luteal phase (day 8) were 49% higher in the migraine group compared to the control group (2Estimate = 1·49, 95% CI: 1·03 – 1·87, p = 0·04), as shown in Table 2. Correspondingly, the decline of plasma estradiol from day 8 to day 14 (luteal phase) was 90% higher in the migraine group compared to the control group (2Estimate = 1·90, 95% CI: 1·16 – 3·12, p = 0·03) (Table 2). Mean estradiol plasma levels with 95% CI bands as presented in Figure 2, which showed a peak on day 8 of 472·0 pmol/L (95% CI: 420·6 – 529·7) in the migraine group compared to 338·4 pmol/L (95% CI: 281·8 – 406·5) in the control group.
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