162 Chapter 7 ONLINE SUPPLEMENTARY FILES Table e-1. Results of a case-crossover analysis in the WHAT-hormone subgroup comparing the odds of a migraine attack on the first day within the ovulatory window versus outside of it. The first analysis includes all control days, while the second excludes control days in the perimenstrual window. Data from 58 menstrual cycles from 31 patients with migraine are shown. Women (n) Migraine attacks (n) Crude OR (95% CI) Control days outside ovulatory window 31 120 1.00 (ref) Ovulatory window 31 16 0·86 (0·80 – 0·92)* Control days outside ovulatory & menstrual window 31 79 1.00 (ref) Ovulatory window 31 16 0·95 (0·88 – 1·02) OR = odds ratio; CI = confidence interval; levels of significance = *≤0·05, **≤0·005, ***≤0·001 Table e-2, Results of SCCS model in the WHAT-hormone subgroup (n=31). Data is stratified per patient and odds-ratios are calculated for start of migraine attack within a certain period of the menstrual cycle, in comparison to follicular phase and luteal phase as reference periods. Reference period Period of interest, OR [95% CI] Follicular phase Luteal phase Intercept 0·09 [0·07 – 0·12] *** 0·05 [0·04 – 0·09]*** Ovulatory window 0·60 [0·34 – 1·03] 1·00 [0·52 – 1·94] Perimenstrual window 1·53 [1·02 – 2·27]* 2·57 [1·51 – 4·39]*** Follicular phase x 1·69 [1·02 – 2·80]* Luteal phase 0·59 [0·36 – 0·99]* x OR = odds-ratio; CI = confidence interval; levels of significance = *≤0·05, **≤0·005, ***≤0·001 Table e-3. Results of mixed logistic regression model in the menstrual migraine subgroup (n =228) with migraine attack as dependent variable and ovulatory window and perimenstrual window as fixed effects and the patient as random effect. Estimate SE p-value OR (95% CI) Intercept -2·31 0·03 <0·001 0·10 (0·09 – 0·11) Ovulation window -0·05 0·05 0·32 0·95 (0·87 – 1·05) Menstrual window 0·63 0·04 <0·001 1·87 (1·69 – 2·02) SE = standard error; OR = odds ratio; CI = confidence interval
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