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139 Rationale and protocol of the WHAT! Trial 6 REFERENCES 1 MacGregor EA, Hackshaw A. Prevalence of migraine on each day of the natural menstrual cycle. Neurology 2004; 63 (2): 351-353. 2 Launer LJ, Terwindt GM, Ferrari MD. The prevalence and characteristics of migraine in a population-based cohort. Neurology 1999; 53 (3): 537. 3 Ripa P, Ornello R, Degan D et al. Migraine in menopausal women: a systematic review. Int J Womens Health 2015; 7: 773-782. 4 Hoshiyama E, Tatsumoto M, Iwanami H et al. Postpartum migraines: a long-term prospective study. Intern Med 2012; 51 (22): 3119-3123. 5 Sances G, Granella F, Nappi RE et al. Course of migraine during pregnancy and postpartum: a prospective study. Cephalalgia 2003; 23 (3): 197-205. 6 Menon R, Bushnell CD. Headache and pregnancy. Neurologist 2008; 14 (2): 108-119. 7 Nappi RE, Albani F, Sances G et al. Headaches during pregnancy. Curr Pain Headache Rep 2011; 15 (4): 289-294. 8 MacGregor EA, Frith A, Ellis J et al. Incidence of migraine relative to menstrual cycle phases of rising and falling estrogen. Neurology 2006; 67 (12): 2154-2158. 9 Somerville BW. The role of estradiol withdrawal in the etiology of menstrual migraine. Neurology 1972; 22 (4): 355-365. 10 Nappi RE, Tiranini L, Sacco S et al. Role of Estrogens in Menstrual Migraine. Cells 2022; 11 (8). 11 Rustichelli C, Bellei E, Bergamini S et al. Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study. Cephalalgia 2020; 40 (12): 1355-1362. 12 Somerville BW. The influence of progesterone and estradiol upon migraine. Headache 1972; 12 (3): 93-102. 13 Calhoun AH. A novel specific prophylaxis for menstrual-associated migraine. South Med J 2004; 97 (9): 819-822. 14 Nappi RE, Terreno E, Sances G et al. Effect of a contraceptive pill containing estradiol valerate and dienogest (E2V/DNG) in women with menstrually-related migraine (MRM). Contraception 2013; 88 (3): 369-375. 15 Morotti M, Remorgida V, Venturini PL et al. Progestin-only contraception compared with extended combined oral contraceptive in women with migraine without aura: a retrospective pilot study. Eur J Obstet Gynecol Reprod Biol 2014; 183: 178-182. 16 MacGregor EA, Frith A, Ellis J et al. Prevention of menstrual attacks of migraine: a doubleblind placebo-controlled crossover study. Neurology 2006; 67 (12): 2159-2163.

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