112 Chapter 5 Subgroup analyses for MO (n = 316) versus low frequent MA (n = 64) and high frequent MA (n = 146) showed no differences for oral contraceptive use and pregnancy (online Supplemental Figure e-1). There was a significant association between migraine diagnosis (MO versus low frequent MA and high frequent MA) and migraine frequency during breastfeeding (p = 0.006). Aura symptoms during hormonal milestones In Figure 3, the effect of oral contraceptive use, pregnancy and menstruation on aura frequency is visualized. The majority of women with MA who used oral contraceptive (current or in the past) (n = 173), reported no change in aura frequency (Figure 3). During pregnancy, the majority of women with MA reported absence of aura symptoms. During menstruation, most MA patients reported no change in aura symptoms (Figure 3). Figure 3. Effect of oral contraceptive use, pregnancy and menstruation on the frequency of aura symptoms in patients diagnosed with migraine with aura (MA), n = 210.
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