87 Table 5 Results of ROC analysis at multiple measuring locations and parameter combinations Sensitivity and specificity were displayed at the optimal cutoff-value. TTT = thermal threshold testing; CDT = cold detection threshold; WTD = warm detection threshold; MLi = method of limits; MLe = method of levels; TSL = thermal sensory limen; PHS = paroxysmal heat sensations; SFNSL = small fiber neuropathy screening list. TTT NOAs at both feet for all parameters except MLe showed more abnormalities in the group with probable SFN compared with the group without SFN and healthy controls (see Figure 4A). TTT NOAs≥2 had the best sensitivity and specificity. Additionally, a higher SFNSL score was found in the group with probable SFN (see Figure 4B). A significant correlation was found between TTT NOAs and the SFNSLscore (see Figure 4C). Figure 4 A: The total number of abnormal thermal threshold test parameters (TTT NOAs) was higher in patients with sarcoidosis and probable SFN (Prob. SFN) compared with patients without SFN (No SFN) and healthy controls (HC). B: The SFNSL-questionnaire also shows higher scores in the group with probable SFN. Note that there is a large dispersion in the group of sarcoidosis patients without SFN. C: A correlation was found between the number of abnormalities in thermal threshold testing (TTT NOAs) and the number of symptoms based on the SFNSL questionnaire. Method Sensitivity Specificity Cutoff value TTT Feet WDT&CDT MLi & MLe (Besta[7]) 8 measurements 60% 55% 1 TTT All parameters and measuring sites 28 measurements 63% 67% 5 TTT All parameters both feet 14 measurements 69% 63% 2 TTT both feet without method of Levels 12 measurements 65% 73% 2 TTT both hands without method of Levels 12 measurements 63% 51% 2 TTT test foot without method of Levels 6 measurements 54% 59% 1 TTT contralateral foot without method of Levels 6 measurements 60% 61% 1 TTT both Feet CDT, WDT & TSL 6 measurements 54% 78% 1 TTT both Feet CDT, WDT, TSL & PHS 8 measurements 66% 67% 1 SFNSL 70% 66% 34 SFNSL & TTT both feet without method of Levels 73% 69% Variable 5 91 5
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