40 Non-small fiber tests Peripheral UltraSound (US) Only one suboptimal study is performed to show potential of this method Level 4 Functional Magnetic Resonance Imaging (fMRI) Only one suboptimal study is performed to show potential of this method No standardized method specific for SFN diagnosis is available143 Level 4 Figure 6 Roadmap; from symptoms to phenotype, from phenotype to diagnostic method. * Many variants are probably nonpathogenic or variant of undetermined significance (VUS). Abbreviations: QSART, quantitative sudomotor axon reflex test; TST, thermoregulatory sweat test; SSR, sympathetic skin response; WISW, water induced skin wrinkling. 42 2
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