180 10 samples of 5 healthy controls and 5 patients with sarcoidosis were sent to the Dutch SFN expertise center to analyze them according to the EFNS guidelines.3 One sample of a patient with sarcoidosis showed a pinch artifact and was therefore excluded. This data showed no association between the results of 50 µm method and our 10 µm method in the same participants. Figure 1 Correlation between 10 µm and 50 µm methods for determining IENFD in 9 participants. IENFD = intraepidermal nerve fiber density The correlation between all combinations of parameters was examined in all participants with sarcoidosis. Except for the SFNSL and TTT NOAs, and skin wrinkling and Sudoscan at the hands, only parameters from the same technique correlated. The SFNSL and TTT NOAs showed a significant correlation (p=0.0001 and R=0.38), and WISW and Sudoscan showed a significant correlation (p=0.001 and R=0.32), see Figure 2. Figure 2 Correlations between symptoms of SFN based on the SFNSL and all diagnostic methods. Abbreviations: SFNSL = small fiber neuropathy screening list; TTT NOAs = thermal threshold testing number of abnormalities; IENFD = intraepidermal nerve fiber density; CNFD = corneal nerve fiber density; CNFL = corneal nerve fiber length; CNDB = corneal nerve branch density; ESC = electrochemical skin conductance; WISW = water immersion skin wrinkling. 188
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