119 Figure 3 Results of the phenotyping questionnaire. A) Example of a completed small fiber neuropathy phenotyping questionnaire (SFNPQ). It shows length-dependent continuous pain in combination with nonlength-dependent intermittent pain. B) Prevalence of length-dependent and non-length-dependent pain for continuous and intermittent presentations (n=48). Continuous non-length-dependent pain was significantly less reported, (OR=0.3, p=0.01, chi-square tested). Correlation between diagnostic methods and patient-reported phenotypes Continuous length-dependent pain was the only patient-reported phenotype that correlated with TTT NOAs (r=0.3, p=0.02) and the SFNSL (r=0.3, p=0.05). Furthermore, TTT NOAs correlated with the SFNSL (r=0.3, p=0.03) (Figure 4A). After dividing the participants into a group with and without continuous length-dependent pain, significantly higher TTT NOAs were found in the group with continuous lengthdependent pain (Figure 4B). Figure 4 Correlation plot of significant correlations. A) Correlation between patient-reported outcome measures and diagnostic methods for SFN. The correlation coefficient ranges between -1 for a negative correlation, 0 for no correlation and +1 for perfect positive correlation (n=48,). B) Boxplots with median TTT NOAs and min-max whiskers for patients with sarcoidosis and probable SFN, with (Present) and without (Absent) continuous length7 125 7
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