118 Table 3 Overview of small fiber neuropathy (SFN) symptoms in patients with sarcoidosis (n=48). SFN symptoms Present (n(%)) Pain 24 (50) Burning sensations 21 (44) Paresthesia 20 (42) Bedsheet/clothing intolerance 10 (21) Headache/dizziness 8 (17) Hypoesthesia/numbness 6 (13) Gastro-intestinal 6 (13) Urinary tract 5 (10) Cold sensation 4 (8) Hot flushes 4 (8) Vision 3 (6) Orthostatic hypotension 2 (4) Absolute numbers of symptoms and percentages were displayed. Phenotypes of SFN Figure 3A shows an example of one participant’s completed SFNPQ. Of the 48 patients with probable SSFN, 17 (35%) showed a length-dependent and 21 (44%) a non-length-dependent phenotype (OR=1.4, p=0.4). Of the 21 patients with a non-length-dependent pain presentation, six reported no pain in the limbs at all. The 10 (21%) patients without cutaneous pain all suffered from muscular or articular pain. For these results, no distinction was made between intermittent and continuous pain. Therefore, the example presented in Figure 3A was identified with a non-length-dependent phenotype. Subsequently, a distinction was made between intermittent and continuous pain. Out of 48 patients with probable SSFN, 13 (27%) patients reported intermittent pain, 11 (23%) continuous pain, and 14 (29%) mixed pain. According to these criteria, the example presented in Figure 3A was classified as intermittent non-length-dependent pain in combination with continuous length-dependent pain. Figure 3B shows which of the four phenotypes were more commonly reported by patients with probable SSFN. Intermittent pain was reported with both, length-dependent and non-lengthdependent presentation without significant difference between the two groups (OR=0.8, p=0.7), while continuous pain was reported more often as length-dependent presentation (OR=0.3, p=0.01, Figure 3B). 7 124 7
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