115 Figure 1 Pain phenotypes; definition of A) length-dependent and B) non-length-dependent pain phenotypes. Phenotypes of patient-reported pain Length-dependent and non-length-dependent phenotypes were distinguished based on patientreported pain symptoms. A length-dependent phenotype was defined as pain starting in the feet and legs with a possible combination of pain in the hands and arms (Figure 1A). A non-length-dependent phenotype could manifest as pain anywhere except the extremities, or in combination with symptoms in the extremities (Figure 1B). Only pain at the skin level could be associated with length-dependent neuropathic pain. This study therefore only shows the results from the first figure indicating neuropathic pain, see Supplementary material for the questionnaire. Results from the questionnaire at muscle, joint and other level (Supplementary material, Figure 2-4) were beyond the scope of this article and therefore not shown in the results section. 7 121 7
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