103 horizontal regression line can be seen in the difference between NFA FIJI and ACCMetrics (Figure 5D). Similar slope directions were available in a previous study.22 Figure 5 Bland Altman plots between, A: CCMetrics and ACCMetrics; B: CCMetrics and NeuronJ; C: ACCMetrics and NeuronJ. Relation between CNFL and NFA The relationship between CNFL and NFA was nonlinear and the slope increased progressively as nerve fiber density increased. A quadratic formula was calculated by Brines et al.21 to describe this relationship: NFA FIJI = 2.78 x 10-4 (NFL)2 + 0.72 (NFL) + 471. According to this exponential formula, NFA increased more than CNFL when the number of corneal nerve fibers increases. The formula was the result of linear regression analysis and the use of passing Bablock technique. Figure 6 showed the formula from Brines et al.21 compared to our data in patients with sarcoidosis. When calculating our own formula with the same technique and programs (ACCMetrics CNFL and NFA FIJI), the line was somewhat shifted to higher values, following approximately the same progression (Figure 6A). However, for CCMetrics and NeuronJ, a root curve (blue) described the relationship instead of exponential growth. As a result, the increase in NFA would decrease as the number of corneal nerve fibers increases (Figure 6B and 6C). 6 108 6
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