Thesis

101 Table 1 Demographics in sarcoidosis patients and healthy controls (mean±std) Group n Age (yrs) Sex Males (n (%)) Height (cm) BMI Disease duration sarcoidosis (yrs) SFNSL Healthy control 20 48±12 10 (50%) 176±9 23±2 3±4 Sarcoidosis without SFN 49 52±11 36 (73%) 178±9 26±4 8±6 25±17 Sarcoidosis with probable SFN 17 50±9 9 (29%) 176±11 29±6 7±8 35±10 Sarcoidosis with established SFN 31 52±9 12 (39%) 176±10 28±6 9±7 44±11 BMI = body mass index; SFN = small fiber neuropathy; SFNSL = small fiber neuropathy screening list; yrs = years Cornea nerve fiber length in small fiber neuropathy Mean CNFL and NFA for the four groups were calculated and ACCMetrics showed significantly higher CNFL and CNFA in patients with symptoms and clinical signs of SFN but with TTT NOA<2, see Table 2 and Figure 4. Table 2 Mean cornea nerve fiber length (CNFL) and nerve fiber area (NFA) calculated with different analysis methods (mean±std). Analysis method Healthy Controls No SFN Probable SFN Established SFN p-value CCMetrics (mm/mm2) 14.7±2.7 14.5±4.5 15.7±3.6 13.3±4.1 0.6 NeuronJ (mm/mm2) 17.5±3.0 17.0±4.1 18.6±4.8 16.1±4.2 0.8 ACCMetrics (mm/mm2) 14.1±2.6 13.2±3.6 15.0± 4.7 12.1±4.3 0.1 NFA FIJI (µm2/mm2) 5101.3±1361.1 4879.2±1408.3 6141.2±1831.0 4781.8±1888.2 0.01 ACCMetrics NFA (µm2/mm2) 4720.0±787.8 4940.8±1422.0 6141.2±2379.1 4990.3±1953.4 0.4 SFN = small fiber neuropathy 6 106 6

RkJQdWJsaXNoZXIy MjY0ODMw